GET THE APP

G6PD Insufficiency, Redox Equilibrium, and Viral Infections: Insinuations for SARS-CoV-2 | Abstract

Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

G6PD Insufficiency, Redox Equilibrium, and Viral Infections: Insinuations for SARS-CoV-2

Author(s): Abhishek Dhawan*, Swarupa Chakole

Abstract

The COVID-19 epidemic has inflicted damage on more than 4 crore 50 lakh people worldwide, resulting in over 10 lakh
deaths. Infestation with the pathogenic SARS-CoV-2 virus leads to excessive inflammation and a cytokine storm, which leads
to cell rupture due to a redox imbalance. The severe type of pneumonia caused by the human coronavirus (hCoV)-SARSCoV-
2 has caused heavy casualties, especially among the old age and those with comorbid illnesses all-inclusive of their age.
The high mortality in African-American males, in general, raises the concern for a possible X-linked modulated process that
could affect the viral pathogenesis and the immune system. When exposed to oxidants or infection, patients who lack the
enzyme Glucose-6-Phosphate Dehydrogenase (G6PD) may have a haemolysis phenomenon. People with a G6PD deficiency
are more prone to take up a virus than people with normal G6PD. G6PD deficiency causes a distinct immunological reaction
to viral infections in people. G6PD insufficiency appears to be a predisposing factor for COVID-19 infection. Glucose-6-
Phosphate Dehydrogenase Deficiency (G6PD) is known to suppress the antioxidant system and is likely to aggravate severity
of COVID-19 infection, which results in a pro-oxidant response leading to higher morbidity and mortality

Share this article

cappadocia tours
cappadocia hotels
cappadocia balloon flights

paper.io

agar io

wormax io