Incidence and Antibiotic Sensitivity of Anaerobic Bacteria in Dentoalveolar Abscess of Diabetic and Non-Diabetic Patients: A Cross Sectional Comparative Study
Background: The presentation of bacterial infection of dental origin is constantly changing and is a measurable reflection of modern evolution of oral flora, the poor host response is multifactorial and diabetes has long been considered as one of the factors reducing host response. Antibiotic resistance patterns may change over time, in Diabetic patient’s frequent use of broad-spectrum antibiotics in the treatment of oral infections and other infections may enhance the development of bacterial resistance. Aim is to compare the incidence, Antibiotic sensitivity of anaerobic isolates from Dentoalvelar abscess of Non-Diabetic and Diabetics. Method: This descriptive study was conducted on 120 patients, both Diabetic (60) and Non-Diabetic (60) patients with Dentoalveolar abscess. Purposive sampling was done. The pus sample collected; cultured (aerobically and anaerobically). Morphological, biochemical, and antibiotic sensitivity tests were done to study the isolates. Statistical analysis was done using unpaired Student’s t test, Chi-square, or Fisher’s exact test, found significant if p <0.05. Results: Anaerobic isolates from Diabetic patients were significantly high, majority were Gram negative isolates. Antibiotic sensitivity was comparable with respect to Metronidazole most sensitive (100%) followed by Amoxicillin/Clavulanic acid (90%). Isolates from Diabetic patients were significantly resistant to Ciprofloxacin (p<0.0001). Conclusions: Anaerobic bacteria are more prevalent in Diabetic patients, anaerobes are subjected throughout life to a continuous challenge by antimicrobial agents used in clinical therapy, high prevalence of bacterial resistance to Ciprofloxacin, Ampicillin suggests the need for regular antibiotic susceptibility tests and rational use of antibiotics in the management of these infections.