Involvement of IL-23 and IL-12 Levels in the Development of Peri?Implantitis
Dental implants: a surgical component that interfaces to the jaw or skull bone to support a dental prosthesis such as a crown, bridge, denture, or facial prosthesis. The aim of this study was to detect the role and related inflammatory cytokines IL-23 and IL-12 in the initiation and progress and evaluate their implication in peri-implant inflammation and their influence upon osseointegration. Material and Methods: 80 subjects (15 peri-implantitits patients and 35 successful implants and 30 healthy controls); the mean age was 43.91 ± 11.33 years, (49 male and 31 female), were attending the department of Oral and Maxillofacial Surgery in the Dental College Teaching Hospital/ Baghdad University, and Shahid Ghazi Hariri Hospital/ Medical City Baghdad, Iraq. Enzyme-linked immunosorbent assay (ELISA) kits were used for the analysis and detection of IL-12 and IL-23. Results: The elevated PISF levels of selected inflammatory cytokines is a result of their activation in the inflammatory process of the peri-implantitis, however, this activation may contribute to peri-implant supportive tissue destruction and bone loss. Conclusion: These results suggest that IL-23 may play an important role in inflammation-mediated bone loss. However, IL-12 exhibits potential as a target for the treatment of pathological bone diseases.