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Phytochemical Analysis, Antioxidant and Anti-Diabetic Activity of Sargassum wightii (A Marine Alga) | Abstract

Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

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Phytochemical Analysis, Antioxidant and Anti-Diabetic Activity of Sargassum wightii (A Marine Alga)

Author(s): Sangiya K and C Naveen Kumar*

Abstract

The edible seaweed, Sargassum wightii, was investigated for its anti-diabetic potential through in vitro enzyme inhibitory assays. Among the various extracts, extracts of petroleum ether and Syl ethyl acetate. Wightii showed significant inhibitory effects against α-amylase. Methanol extract for S. wightii showed very high inhibition against dipeptidyl peptidase and moderate antioxidant activity was observed in the release of acetone S. wightii. Similarly, the hexyen extract of S. polycystum showed very high inhibition against α-amylase and S-extract methanol. Polycystum inhibition significantly against α-glycosidase as well. The antioxidant activity was negative. Exit was investigated with in vitro cytotoxicity, DNA fragmentation in macrophages and hemolytic activity against erythrocytes, but no significant toxicity was detected by any of the extracts. Gas chromatography – mass spectrometry reveals the presence of anti-diabetic compound fucosterol and other major bioactive compounds, providing insight into the anti-diabetic and antioxidant properties of this compound. This study revealed possible mechanisms of anti-diabetic in vitro action, and these two marine plants may have anti-diabetic action in vivo. Seaweed, that is, the great seaweed, comprises a group of photosynthetic plants, which it is believed that evolution did not extend to the earth's vegetation. In general, the morphology of algae is much simpler than that of plant plants. There is a limited variety of functional cells and, indeed, many known unicellular algae are scientifically related to marine plants. To date as algae metabolism has been studied, it appears to be similar in many ways to earthy plants, although the final metabolic product may be different.

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