Serum Calcium and Vitamin D Levels in Type 2 Diabetes Mellitus
Author(s): Kanchana R*
Individuals with T2DM do not experience this increase in b-cell mass, in fact there is a significant decrease in b¬ cell mass. In addition to a decrease in b-cell mass, there is a 41% decrease (p<0.05) in relative b-cell volume. Individuals with T2DM when compared to their lean non diabetic counterparts, which can be partially explained by the increase in b-cell apoptosis that is also observed in individuals with T2DM. Finding suggests that b-cell apoptosis may be more pronounced in individuals with T2DM partly due to an increase in caspase-3 activity, and that it may contribute to the decrease in b-cell mass observed in this study- . The targeting of beta cell function early in the pathogenesis of T2DM is considered a critical intervention for the prevention of the diseases. It was also observed that the T2DM individuals with a vitamin D insufficiency showed a poor glycaemic control.