The Effect of Tellurium Oxide Micro Particles Incorporation into PMMA on Candida Albicans Adherence
Background: For centuries, naturally accessible items have been widely used in the treatment of human disease. The current study aimed to scientifically determine the antifungal effectiveness of tellurium oxide against Candida Albicans adherence to polymethelmethacrylate (PMMA) material. Methods: The antifungal ability of tellurium oxide evaluated against Candida Albicans adherence by incorporation of TEO into PMMA monomer in concentration (1%, 3%, 5%, 7% by wt.). Twenty five samples were prepared and divided into five groups (control group and four experimental groups), five samples for each group. The sterile PMMA samples were placed in sterilized tubes containing Sabouraud dextrose broth, in which a small quantity of the isolated yeast was suspended, and incubated at room temperature for 1 hour. The specimens were then removed, rinsed with phosphate buffered saline, dried, fixed with methanol, stained with crystal violet, and viewed under an inverted light microscope. Results: The adherence test results revealed a significant decrease in the number of Candida cells adherent to PMMA after adding 3% and 5% Tellurium oxide compared to samples from the control group, 1% and 7% experimental group. In conclusions, the results of current study encourage use TEO as antimicrobial material in different ways. Conclusion: Incorporating the Tellurium oxide powder into heat cure acrylic material can succeed in producing a heat cure acrylic material with antifungal activity against Candida micro-organisms.