Joana Leticia Vendruscolo
Department of Oral and Maxillofacial Surgery, Erasto Gaertner Hospital, Curitiba, Paraná, BrazilPublications
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Review Article
Evaluation of epithelial-mesenchymal markers and correlation with clinical aspects in keratocyst lesions
Author(s): Joana Leticia Vendruscolo, Mariana de Souza Lessa, Sergio Ossamu Ioshii, Juliana Lucena Schussel and Laurindo Moacir Sassi*
Objective Odontogenic keratocysts (OK) have a high recurrence rate and aggressive clinical behavior. The event called epithelial-mesenchymal transition (EMT) is a process in which the epithelial cell loses its epithelial characteristics and acquires properties typical of mesenchymal cells. Studies have already demonstrated that OC has expression of tumor markers, but the lack of clarification about its development mechanism and molecular composition makes the therapeutic options remain limited. The aim of this study is to evaluate the expression of EMT marker proteins in these lesions, correlating the expression of these proteins with clinical aspects of each case. Method Patients with OK diagnoses, treated by the Department of Oral and Maxillofacial Surgery of the Erasto Gaertner Hospital, Curitiba, Brazil in the period betwe.. Read More»