Mohammed Nadeem Bari
Department of Basic Medical Sciences, College of Medicine, Prince Sattam bin Abdulaziz University, Al-Kharj, 11942, Saudi ArabiaPublications
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Research
Extraction of Antimicrobial Peptides (AMP) from Portunus sanguinolentus Herbst Perna viridis Linneaus and Octopus indicus Orbigny Identifying the best Solvent for AMP Recovery and Determining its Anti Eskape Activity
Author(s): Muhammad Musthafa Poyil*, Mohammed Nadeem Bari, Sanjay Prasad S and Mamoun A Alfaki
The indiscriminate overuse and misuse of antibiotics worldwide has resulted in high rates of antimicrobial resistance, raising new human health challenges WHO has reported antimicrobial resistance (AMR) as one of the emerging world crises. High level of drug resistance was reported in ESKAPE pathogens which cause most infections within the hospital environment. Marine organisms’ synthesis antimicrobial peptides (AMP) for itself defence against several pathogenic microorganisms. Thus the present study focuses on extraction of AMP from three marine invertebrates Portunus sanguinolentus Herbst (crab), Perna viridis Linneaus (Mussel) and Octopus indicus Orbigny and determining its anti-ESKAPE activity against Escherichia coli, Enterococcus faecalis, Staphylococcus aureus, Klebsiella pneumonia, Pseudomonas aeruginosa and Acinetobacter baumanni. The best solvents among Ethanol, Methan.. Read More»