Oguzhan Kavrik

Department of Physiology, Faculty of Medicine, S├╝leyman Demirel University, Isparta, Turkey


  • Research   
    Healing effects of agomelatine on methotrexate-induced Kidney damage in rats
    Author(s): Nurhan Gumral, Ozlem Ozmen, Rahime Aslankoc, Arzu Yalcin* and Oguzhan Kavrik

    MTX is a chemotherapeutic agent widely used in the treatment of some types of cancer (as in acute lymphoblastic leukemia and lymphoma) as well as inflammatory disorders as rheumatoid arthritis. Agomelatonin is a molecule synthesized and released in the pineal gland as a synthetic anologue of the hormone melatonin. Agomelatonin has a strong agonist effect on the melatonin hormone receptors MT1 and MT2. Twenty-four 3-4 months old male Wistar albino rats were randomly divided into three groups of eight rats. MTX group was administered a single dose of 20 mg/kg MTX i.p. on the second day of the experiment. Ago group a single dose of 40 mg/kg AGO was given by oral gavage for 7 days. AGO group, BUN and creatine levels decreased statistically significantly compared to the MTX group. There was a statistically significant increase in TAS levels in the AGO group compared to the MTX group (p=0.0.. Read More»

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