Sachin Agrawal
Department of Medicine, Jawaharlal Nehru medical college, Datta Meghe Institute of Medical Sciences (Deemed to be University), Wardha, Maharashtra, IndiaPublications
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Research Article
Serum Lactic Acid as a Prognostic Marker in Clinical Medicine
Author(s): Praraj Jaiswal* and Sachin Agrawal
Body tissues under stresses, such as hypoxia, inflammation, sepsis, and shock, trauma, and organ failure resort to anaerobic respiration under low oxygen availability. This prompts cells to resort to anaerobic respiration as a means of producing ATP. Lactic acid is one of the by-products of anaerobic respiration. It is an anti-inflammatory agent and inhibits formation of pro-inflammatory mediators such as interleukin 12 and TNF (Tumour Necrosis Factor) in tissues and increases formation of interleukin 10 (Anti-Inflammatory). Therefore, it can be postulated that an increase in lactic acid levels in the blood can indicate an increased level of inflammation in the body, since anti-inflammatory chemicals will be secreted in response to an increase in inflammatory mediators. A prognostic marker is a biochemical used to measure the progress of a disease. Based on the above hypothesi.. Read More»