Senol Dane
NigeriaPublications
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Research
Selenium-Yeast Administration Ameliorates the Alterations in Haematological and Oxidative Stress Parameters of Wistar Rats Subjected to Restraint Stress
Author(s): Okwute M Ochayi, Ruth Y. Manjak, Emmanual E Ochai, Oluwatosin I Oyeniran and Senol Dane*
Introduction: Stress is a classical experience of “wear and tear” on physiological systems emanating from the central nervous system to other body systems. The blood acts as intermediary among the hypothalamic-pituitary-adrenal system and tissues of an organism and is among the first tissues opened to oxidative stress. This study aims to investigate the haematological changes that accompany restraint stress and the ameliorative roles of a selenium-yeast antioxidant. Materials and Methods: Fifteen (15) Wistar rats were separated into three groups of five each (n=5); Group I (normal control), Group II- (selenium yeast (0.1mg/kg) + restrained stress), and Group III (stress control; restraint stress + distilled water 1ml/kg). Restraint stress was by restraint meshes from (9:00 h- 15:00 h) for 21 days, and rats were decapitated afterward. Blood sample (3 mL) was collected by ca.. Read More»