Vladimir V Gureev
Department of Medical and Dental Science, Belgorod State National Research University, Belgorod, RussiaPublications
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Research Article
Correction of the Endothelial Function and the Hemostasis System Disorders with Ademethionin and Taurine in Model Associated with ADMA-Like Preeclampsia
Author(s): Tatiana G Pokrovskaya*, Taisiya A Khadieva, Vladimir V Gureev, Vladimir M Pokrovskii, Evgenii A Patrachanov, Igor B Kovalenko, Vladimir I Shutov and Alexey A Shabalin
Objective: The aim of this study is to evaluate the effectiveness of pharmacological correction of functional disorders of endothelial function and the hemostasis system with ademethionin and taurine in ADMA-like preeclampsia model as a serious problem of modern medicine. Materials and methods: Simulation of ADMA-like preeclampsia was performed by intraperitoneal injection of L-NAME to females in the same doses for 7 days (14-20th days of pregnancy). Deficiency of nitric oxide in result of the blockade of NOsynthase was accompanied by violation of endothelium dependent and endothelium undependentvasodilation assessed in pharmacological trials, which was reflected in the increase of the coefficient endotelialny dysfunction. The platelet aggregation induced by ADP, collagen, ristomycin, adrenaline was determined, as well as PTT, T.. Read More»