Zeinab G Younus
Department of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, IraqPublications
-
Review Article
Synthesis, characterization and evaluation of antioxidant activity of New pyrazolines derivatives
Author(s): Zeinab G Younus* and Tagreed NA Omar
A series of pyrazoline antioxidant derivatives were synthesized from chalcones and evaluated for their pharmacological activities. Chalcones (1-6) were prepared by claisen schimidt condensation methods by the reaction of furfural with different acetophenones. Various pyrazolines derivatives were prepared by reflux reaction of chalcones (1-6) with hydrazine/hydrazine hydrate in ethanol and glacial acetic acid which refluxed in hot water bath at temperature 50°C for about 2-3 hours, using one pot reaction. To form pyrazoline II (1-6), then antioxidants compounds (a: Eugenol and b: Vanillin) was added; reflex for two hours, cool the reaction mixture in ice water bath until crystal formation is complete. Add ice cold water to the flask and the product was filtered, washed with water and then dried to get pyrazoline antioxidant derivatives, III a (1-6) and III b (1-6). The structures o.. Read More»