Cause-Effective Relations between Vegetative Status and Inflammation Factors in the Formation of Essential Arterial Hypertension in Children
Author(s): Agzamova Shoira Abdusalamovna*, Akhmedova Firuza Mirzakirovna, Makhkamova Gulnoza Turaxodjaevna, Shaykhova Munira Ikramovna
Study of causal relationships between vegetative status and inflammatory factors (highly sensitive C-reactive protein (CRP-hs), tumor necrosis factor-alpha (TNF-α) and anti-inflammatory interleukin-10 (IL-10) in the formation of essential arterial hypertension in children established the heterogeneity of the ergo- and trophotropic effects of the autonomic nervous system on the activity of pro- and anti-inflammatory cytokines and the level of cortisol. The clinical course of essential arterial hypertension in children is manifested by functional abnormalities, tense functioning of the autonomic nervous system, subclinical inflammation with an increase in the level of TNF-α, CRP-hs and a decrease in IL-10, which has features depending on the form of essential arterial hypertension. Increased secretion of cortisol in the group of children with arterial hypertension and the establishment of correlations different from the control and comparative groups between the studied parameters indicate a changed in the stress-realizing system of the body with overstrain of the neuroendocrine channel of blood pressure regulation with the activation of the pro-inflammatory cytokine TNF-α, which is the trigger mechanism for the formation of arterial hypertension. These changes, apparently, are characteristic of chronic stress of inflammatory genesis, which determine the pathogenetic significance in the development of essential arterial hypertension in children.