Coronary Implants Coated with Rapamycin and Heparin to Retard Bacterial Adhesions and Restenosis: An Experimental Study
Author(s): Tariq Majed Alfauri*, Bader Ghanem Alanazi, Jawaher Ghanem Aldawsari, Fatimah Mohammed Alenazi, Radhi Ghanem Alanazi, Abdullah Abdlulmajeed Ali and Ahmad Sheihan Alonazi
Abstract
Background: Atherosclerosis is a common type of coronary artery disease caused by occlusion of coronary arteries. Plaque narrows and hardens the arteries. Stent implantation is considered to be the most successful treatment for atherosclerosis. Hyperplasia and bacterial adhesion are complications found among stent implanted patients. Methods: The present research investigates solving the dual problems of restenosis and bacterial adhesion using a rapamycinheparin mixture impregnated with cyclodextrin as a carrier. Drug discharge analysis using HPLC, the bacterial adhesion ability of organisms, and the inhibitory effect of drug-coated stents were evaluated. The uniform coating of drugs on the stents can be observed under scanning electron microscopy. Results: The discharge of drugs from a coated stent surface was analysed for a maximum of 144h. Polymer degradation occurred and the mean concentration release remained almost constant from 72h to 144h, indicating the sustained release of drugs from the coated stents. Strong bacterial adhesion-producing organisms, Staphylococcus aureus (0.28) and Escherichia coli (0.27), showed a 29.4 ± 1.7mm and 23.2 ± 0.8mm zone of inhibition. Conclusion: The dual role of stents in preventing bacterial adhesion-associated infection and restenosis was achieved. Thus, a rapamycin-heparin coated drug with a cyclodextrin carrier can be considered as a novel product in the biomedical industry, with respect to its constant drug releasing ability. mp3download.link Best YouTube to MP3 converter. Download MP3 from YouTube for Free. one would honestly have expected more on the track mp3-go.net Download Mp3 songs for free Given the legendary pedigree of the man behind the sound downloadmp3-gratis.biz Download mp3 songs online at Mp3 Converter, watch high quality online music videos download-mp3gratis.me watch and download free songs of the highest quality. Listen to songs online here comfortably without any annoying advertisements. metrolagu.com Easy to use and free MP3 downloader. YouTube To MP3 download in seconds using the best YouTube to MP3 converter. YouTube Mp3 Get the latest song by simply typing the latest artist or song title in the Search menu. Mp3 file format with 128 - 320 Kbps bitrate converted from YouTube videos. read at this blog All those artist performances are still available on YouTube today find more here