Abdullah Abdlulmajeed Ali
King Saud Bin Abdulaziz University for Health Sciences, Saudi ArabiaPublications
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Research
Coronary Implants Coated with Rapamycin and Heparin to Retard Bacterial Adhesions and Restenosis: An Experimental Study
Author(s): Tariq Majed Alfauri*, Bader Ghanem Alanazi, Jawaher Ghanem Aldawsari, Fatimah Mohammed Alenazi, Radhi Ghanem Alanazi, Abdullah Abdlulmajeed Ali and Ahmad Sheihan Alonazi
Background: Atherosclerosis is a common type of coronary artery disease caused by occlusion of coronary arteries. Plaque narrows and hardens the arteries. Stent implantation is considered to be the most successful treatment for atherosclerosis. Hyperplasia and bacterial adhesion are complications found among stent implanted patients. Methods: The present research investigates solving the dual problems of restenosis and bacterial adhesion using a rapamycinheparin mixture impregnated with cyclodextrin as a carrier. Drug discharge analysis using HPLC, the bacterial adhesion ability of organisms, and the inhibitory effect of drug-coated stents were evaluated. The uniform coating of drugs on the stents can be observed under scanning electron microscopy. Results: The discharge of drugs from a coated stent surface was analysed for a maximum of 144h. Polymer degradation occurred and the mean .. Read More»