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Effectiveness of Papain as an Anti-Inflammatory Agent in Patients Undergoing Surgical Removal of Impacted Teeth-A Randomized Double Blinded Clinical Trial | Abstract

Journal of Research in Medical and Dental Science
eISSN No. 2347-2367 pISSN No. 2347-2545

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Effectiveness of Papain as an Anti-Inflammatory Agent in Patients Undergoing Surgical Removal of Impacted Teeth-A Randomized Double Blinded Clinical Trial

Author(s): Vivek D Menon and MR Muthusekhar*

Abstract

Background: The most common drugs used for treatment of both acute and chronic inflammation include both steroidal and non-steroidal anti-inflammatory drugs (NSAIDs).. However, drugs from both these groups are saddled with many side effects. Corticosteroids for example can cause peptic ulcer disease, raised blood pressure and glucose levels. NSAIDs meanwhile can cause severe complications such as peptic ulcer disease, renal impairment and elevate the risk of developing heart failure. Thereby, the emergence of several alternative anti-inflammatory drugs such as enzyme-based serine proteases have been thought to be a safer option in patients needing acute or chronic reduction of inflammation. Materials And Method: The study was conducted on 60 patients of either sex between the age group of 18-40 years who required removal of impacted third molar teeth Group 1:- comprising of 30 patients received the drug of papain for three times a day for five days.(500 mg) Group 2: comprising of 30 patients received conventional therapy. Measurement of facial swelling was made preoperatively and on the first, third and seventh postoperative day. Pain was evaluated from the patient's response to visual analogue scale (VAS). Results: Group 1 with Papain showed a significant reduction in facial swelling when compared to Group 2(Control).When considering analgesic effect papain showed a significant reduction in pain compared to Control group. Conclusion: Use of papain appears to be associated with reduction of soft tissue swelling and improved mouth opening when compared to conventional therapy (placebo).

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