Fayez Alghofaili

Department of Medical Laboratory Sciences, College of Applied Medical Sciences, Majmaah University, Majmaah 11952, Saudi Arabia


  • Research   
    Evaluating the Role of an Outer Membrane Lipoprotein Cj1279c in the Pathogenesis of Campylobacter jejuni
    Author(s): Fayez Alghofaili*

    Campylobacter jejuni is considered to be the most common bacterial cause of human gastroenteritis worldwide, and is often acquired from contaminated poultry products. However, fundamental aspects of its pathogenesis remain poorly understood. Proteomic technology and bioinformatic analysis have identified a number of membrane-associated proteins including lipoproteins in C. jejuni. Among those proteins is (designated Cj1279c), which seems to be involved in the interaction of C. jejuni with the host cell surface and contribute to pathogenesis. Cj1279c contains at least three fibronectin type III domains, which often associated with cell surface binding. Importantly, it has been found to be required for chicken colonization in vivo and efficient binding to LMH chicken cells in vitro. The Cj1279c gene is highly conserved in eight C. jejuni genome sequences. The aim of this study was to ex.. Read More»

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