Ganga Raju M

Department of Pharmacology, Gokaraju Rangaraju College of Pharmacy, Hyderabad, India


  • Research   
    Development, Characterization and Evaluation of Nano Formulation of Abrus Precatorius Root Extract for Anti Inflammatory Activity
    Author(s): Sneha Nawale*, Sindhu Bhargavi M, Prasanna Laxmi K and Ganga Raju M

    The aim of the present study was to develop nano formulation of Abrus precatorius root extract (NE-AP) and characterize for particle size, poly dispersed index (PDI), entrapment efficiency, zeta potential, SEM, XRD and differential scanning microscopy (DSC). NE-AP was assessed for its anti-inflammatory potential with carrageenan induced rat paw edema, formalin induced rat paw edema and cotton pellet granuloma in rats. Average particle size of NE-AP was found 35 nm, PDI 60%, entrapment efficiency 46%, zeta potential -23mV. XRD showed the characteristic peaks at 32, 41 and 67 θ. SEM revealed the spherical shape and smooth surface of particle, and in DSC melting endotherm was observed at 329.37º C. NE-AP (50 mg/kg bd.wt and 100 mg/kg bd.wt) showed significant antiinflammatory activity with carrageenan induced inflammation (p˂0.01, p˂0.05), formal.. Read More»

    Abstract HTML PDF