Median Atia Alkhalaf Almamou

Sarajevo Medical School, University of Sarajevo School of Science and Technology (SSST), Sarajevo, Bosnia and Herzegovina, IVF Unit, Obstetrics and gynaecology Department, Almoosa Specialist Hospital, Saudi Arabia


  • Research   
    Study of Endometrial and Uterine Doppler Markers when Using Letrozole and Clomiphene Citrate in Subfertile Patients with PCOS or Unexplained Subfertilit
    Author(s): Median Atia Alkhalaf Almamou* and Asim Kurjak

    Background: Clomiphene citrate has agonist and antagonist estrogen receptor properties with a discrepancy between pregnancy rate and ovulation rate. Letrozole works as a competitive, nonsteroidal aromatase inhibitor. Both stimulate ovarian follicles development. Methods: In this randomized prospective study, We recruit infertile Patients with PCOS or unexplained subfertility from the subfertility clinic at Al Moosa Specialist Hospital. We randomized patients to use either clomiphene or letrozole. On the day of the hCG trigger and the mid-luteal day, we recorded Endometrial thickness, pattern, blood flow, endometrial scoring system, uterine artery and sub endometrial arteries Doppler indices. Results: The mean of sub endometrial artery PI and RI on the day of the trigger was lower with the clomiphene treated patients than the letrozole treated patients with a p-value of .0003 and .0004.. Read More»

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