Mahnaz Fatahinia
Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, IranPublications
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Research
In vitro Activity of New Azole Luliconazole Compared to Fluconazole against Candida Strains Isolated from Oral Lesions of Cancer Patients
Author(s): Mehrnoush Maheronnaghsh, Parvin Dehghan, Mahnaz Fatahinia* and Ali Rezaei-Matehkolaei
Introduction: Oral candidiasis is the most common fungal infection in patient's undergone chemotherapy. The aim of this study was to investigate the incidence and causative agents of oral candidiasis along with in vitro activity of new azole luliconazole compared with fluconazole against agents of oral candidiasis in a population of cancer patients. Materials and Methods: A total of 385 oral samples from patients with various types of cancer and undergone chemotherapy were subjected to fungal culture. The yeast isolates were then identified by using PCR-RFLP method. The MIC values for fluconazole and luliconazole were determined using broth microdilution according to the M27-S3 protocol of the CLSI. The MICs, MIC50, MIC90 and geometric mean (GM) values were evaluated for all the isolates. Results: Totally, 36 y.. Read More»