Mohammed H Karrar Alsharif
Department of Basic Medical Sciences, College of Medicine, Prince Sattam Bin Abdulaziz University, Al-Kharj, 11942, Saudi ArabiaPublications
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Research
Anatomical Abnormalities Caused by Induced Infections in Femur and Tibia of Rattus Norvegicus and the Efficacy of Marine-Derived Antimicrobial Peptides (AMPS) in Treatment
Author(s): Mohammed H Karrar Alsharif*, Muhammad Musthafa Poyil, Nagi Mahmoud Bakhit, Elmutasim O Ibnouf, Abubaker Y Elamin, Juman M Almasaad, Khalid M Taha, Abair Awadalla Ahmed Mahdi, Mohamed Suliman, Mamoun A Alfaki and Hala M Hamour
This study aimed to assess the impact of gill extraction of antimicrobial peptides which are derived from the marine organism Perna Viridis against anatomical abnormalities. Those have been developed due to induced bacterial infection in the tibia and femur of Rattus norvegicus. Such infections are maintained for three weeks. Methods and Results: Experimental infection was induced in 2 Albino rats. A 109CFU/ml suspension of Staphylococcus aureus and streptococcus pyogenes was injected into the tibia and femur of the experimental rat. On observation of two rats, the clinical symptoms like inflammation, tumours, and histopathological changes. Among histopathological changes mostly inflammatory cells like monocytes, T-lymphocytes, neutrophils were observed more than basophils over the tissue in "Staphylococcus aureus (S.A.)".. Read More»