Erdem Karabulut
Department of Biostatistics, Faculty of Medicine, Hacettepe University, Ankara, TurkeyPublications
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Research
Investigation of TNF-?, LT-? and TNFR-2 gene Polymorphisms in Patients with Periodontitis in Turkey
Author(s): Selin Özkan-Kotiloğlu, Gülcan Kuyucuklu, Esra Baltacioglu*, Güliz Güncü, Erhan Dursun, Erkan Sukuroglu, Erdem Karabulut, Emine Sibel Sümer and Ferda Alev Akalın
Introduction: One of the cytokines involved in periodontal breakdown in periodontitis is; Tumor necrosis factor (TNF), with two types; tumor necrosis factor-α (TNF-α) and lymphotoxin-α (LT-α). Aim: In the present study, the individual frequency of TNF-α -308 promoter, LT-α +252 intron, and TNF receptor-2 (TNFR-2) +587 exon polymorphisms associated with chronic (CP) and generalized aggressive periodontitis (GAP) were evaluated in Turkish population. Materials and Methods: This research was conducted on 224 periodontitis patients (P) (119 CP, 105 GAP patients) and 85 healthy controls (C). Blood samples were collected, and specific DNA regions were amplified by PCR method. Investigated gene polymorphisms were determined by RFLP (Restriction Fragment Length Polymorphism). Statistical analyses, including linkage analyses were performed. Results: While th.. Read More»